Endocrine Abstracts

Background: Distant metastasis rarely occurs in differentiated thyroid carcinoma (DTC), but represents most common cause of death in patients with DTC. Lung and bone are the most frequent sites of distant metastases. This study investigated long term outcomes of lung metastasis in DTC patients and its prognostic factors influencing disease progression and cancer specific survival (CSS).Methods: A total of 134 DTC patients presenting with lung metastasis ...

Background: Early detection of residual or recurrent cancer in patients with differentiated thyroid cancer (DTC) is important, especially, when they do not uptake 131I uptake because these tumors do not likely benefit from radioiodine therapy (RAIT). We aimed to evaluate the usefulness of FDG-PET/CT as an early diagnostic work up in DTC patients with negative radioiodine whole body scan (I-WBS) and elevated stimulated Tg (sTg) levels.Methods: ...

Background: Urinary metanephrine (MN) and normetanephrine (NMN) are used to detect recurrence of pheochromocytoma during post-operative period. Currently, reference ranges of urinary MN and NMN obtained from healthy individuals are applied to subjects with adrenalectomy. However, studies regarding the property of using reference ranges from healthy subjects in pheochromocytoma subjects with adrenalectomy are limited.Aim: To compare urinary MN and NMN con...

Background/aims: Maternal subclinical hypothyroidism has been reported to be associated with risks of adverse pregnancy outcomes such as fetal loss and possible fetal neurodevelopmental deficit. However, current guidelines seem to overestimate subclinical hypothyroidism in pregnant women in some regions. Therefore, we aim to evaluate trimester-specific reference range of serum TSH for pregnant women in Korea and whether maternal subclinical hypothyroidism affects perinatal out...

Background: PD-1/PD-L1 blockade is one of the promising drugs in the treatment of advanced non-small cell lung cancer (NSCLC). and predicting drug effect is important due to unique pattern of response. Immune-related adverse event (IRAE) might be associated with favorable clinical outcome. Thyroiditis is the most common IRAE which can be easily detected with the measurement of thyroid hormone levels. However, the relationship between thyroid dysfunction during the use of PD-1/...

Background: Three deiodinase genes (DIO) play an important role in thyroid hormone metabolism. Among them, type 2 iodothyronine deiodinase (DIO2) converts T4 to T3 in brain and impaired psychological well-being was reported in minor variants of DIO2. However, the prevalence of three DIOs and their relation to neuropsychological status has not been evaluated in Asian hypothyroid subjects.Methods: We prospectively enrolled 196 subjects who were taking levo...

Background: Recent studies have shown associations of thyroid hormone levels with metabolic syndrome (MetS) among euthyroid individuals, though there have been some inconsistencies. We evaluated the relationships between thyroid hormones and MetS in euthyroid middle-aged subjects in a large cohort.Methods: Retrospective analysis of 13 496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were gro...